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D Warren Spence Selected Research

Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome)

1/2011Pharmacotherapy of insomnia with ramelteon: safety, efficacy and clinical applications.
8/2008The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders.
7/2008Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways.
3/2008Therapeutic potential of melatonin agonists.
1/2008Jet lag: therapeutic use of melatonin and possible application of melatonin analogs.
1/2007Role of the melatonin system in the control of sleep: therapeutic implications.

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D Warren Spence Research Topics

Disease

8Sleep Initiation and Maintenance Disorders (Insomnia)
06/2013 - 01/2004
6Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome)
01/2011 - 01/2007
3Sleep Wake Disorders
09/2011 - 03/2008
3Depressive Disorder (Melancholia)
06/2011 - 07/2008
3Neoplasms (Cancer)
06/2011 - 09/2008
3Jet Lag Syndrome
01/2011 - 01/2007
2Parkinson Disease (Parkinson's Disease)
04/2013 - 09/2011
2Neurodegenerative Diseases (Neurodegenerative Disease)
04/2013 - 01/2011
2Major Depressive Disorder (Major Depressive Disorders)
06/2011 - 03/2008
2Inflammation (Inflammations)
03/2011 - 12/2010
2Septic Shock (Toxic Shock Syndrome)
01/2011 - 12/2010
2Glaucoma
08/2010 - 07/2008
2Seasonal Affective Disorder
02/2009 - 01/2008
2Hepatocellular Carcinoma (Hepatoma)
09/2008 - 07/2008
1Schizophrenia (Dementia Praecox)
06/2013
1Disease Progression
06/2013
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
04/2013
1Brain Edema (Cerebral Edema)
04/2013
1Huntington Disease (Huntington's Disease)
04/2013
1Alzheimer Disease (Alzheimer's Disease)
04/2013
1Stroke (Strokes)
04/2013
1Traumatic Brain Injuries (Traumatic Brain Injury)
04/2013
1Cognitive Dysfunction
06/2011
1Type 2 Diabetes Mellitus (MODY)
03/2011
1Metabolic Syndrome (Dysmetabolic Syndrome X)
03/2011
1Insulin Resistance
03/2011
1Mitochondrial Diseases (Mitochondrial Disease)
01/2011
1Sepsis (Septicemia)
12/2010
1Virus Diseases (Viral Diseases)
12/2010
1Uveitis
08/2010
1Pain (Aches)
03/2010
1Neuralgia (Stump Neuralgia)
03/2010
1Acute Pain
03/2010
1Headache (Headaches)
03/2010
1Hyperalgesia
03/2010
1Parasitemia
01/2010
1Malaria
01/2010
1Substance Withdrawal Syndrome (Withdrawal Symptoms)
06/2009
1Colorectal Neoplasms (Colorectal Cancer)
09/2008
1Endometrial Neoplasms (Endometrial Cancer)
09/2008
1Liver Neoplasms (Liver Cancer)
09/2008
1Breast Neoplasms (Breast Cancer)
09/2008
1congenital stationary Night blindness
08/2008
1Ganglion Cysts (Ganglion)
07/2008
1Prostatic Neoplasms (Prostate Cancer)
07/2008
1Melanoma (Melanoma, Malignant)
07/2008
1Substance-Related Disorders (Drug Abuse)
03/2008
1Rheumatoid Arthritis
01/2008
1Mood Disorders (Mood Disorder)
01/2008
1Neurodevelopmental Disorders
01/2007
1Autistic Disorder (Autism)
01/2007
1Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
01/2007

Drug/Important Bio-Agent (IBA)

19MelatoninIBA
04/2013 - 01/2004
6ramelteon (Rozerem)FDA Link
06/2011 - 01/2007
4agomelatine (S20098)IBA
06/2011 - 01/2007
4Melatonin Receptors (Melatonin Receptor)IBA
01/2011 - 07/2008
3Pharmaceutical PreparationsIBA
06/2013 - 06/2009
3Free RadicalsIBA
04/2013 - 03/2010
3Antidepressive Agents (Antidepressants)IBA
06/2011 - 01/2009
3Hypnotics and Sedatives (Sedatives)IBA
06/2011 - 01/2007
2Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
06/2011 - 01/2009
2Nitric Oxide Synthase (NO Synthase)IBA
12/2010 - 03/2010
1Neurotransmitter Agents (Neurotransmitter)IBA
06/2013
1Neuroprotective AgentsIBA
04/2013
1BenzodiazepinesIBA
06/2011
1MT2 Melatonin ReceptorIBA
06/2011
1Proteins (Proteins, Gene)FDA Link
03/2011
1Adenosine Triphosphate (ATP)IBA
01/2011
1Anti-Inflammatory Agents (Anti-Inflammatories)IBA
12/2010
1EnzymesIBA
12/2010
1AntioxidantsIBA
12/2010
1Peroxynitrous Acid (Peroxynitrite)IBA
12/2010
1Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2010
1Formaldehyde (Formol)FDA Link
03/2010
1Analgesics (Analgesic Drugs)IBA
03/2010
1EndotoxinsIBA
03/2010
1Type C PhospholipasesIBA
01/2010
1Androgen Receptors (Androgen Receptor)IBA
09/2008
1Linoleic Acid (Linoleate)IBA
09/2008
1Diethylnitrosamine (N-Nitrosodiethylamine)IBA
09/2008
1AndrogensIBA
09/2008
1AcidsIBA
09/2008
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
07/2008
1Retinaldehyde (Retinal)IBA
07/2008
1Hormones (Hormone)IBA
03/2008
1Therapeutic UsesIBA
01/2008

Therapy/Procedure

1Off-Label Use
01/2011
1Drug Therapy (Chemotherapy)
01/2011
1Ligation
03/2010
1Operative Surgical Procedures
03/2010
1Therapeutics
01/2007
1Acupuncture Therapy
01/2004